Param

Value

Units

Biological Interpretation

a

864

glucose production rate by liver when G = 0

b

1.44

glucose clearance rate independent of insulin

c

0.72

insulin induced glucose uptake rate

d

43.2

β-cell maximum insulin secretory rate

e

20,000

gives inflection point of sigmoidal function

f

432

whole body insulin clearance rate

g

0.06

β-cell natural death rate

h

0.84e-3

determines β-cell glucose tolerance range

i

0.24e-5

determines β-cell glucose tolerance range

K

900

Environmental capacity

r

0.01

growth rate of β-cells

α

0.01

inverse of half saturation constant